KTNV reported that the crash happened just after 1 p.m. on I-15 northbound in Las Vegas, according to the Nevada Highway Patrol.
KTNV also reported that multiple cars were involved in the crash, including four cars in Senator Reid's caravan.
The extent of Reid's injuries were not immediately clear, but staff members reported that the senator was able to walk under his own power into the hospital.
Reid attended Utah State University and is a member of the Church of Jesus Christ of Latter-day Saints.
Stay tuned to ABC 4 News and ABC4.com for more on this story.
----Information from: KTNV.